描述与终身甲基暴露相关的风险:使用人口内部暴露的全球方法
Thomas Gastellu1, Anna Mondou2, Marie Bellouard3
1Oniris, INRAE, LABERCA, Nantes, 44300, France; Risk Assessment Department - French Agency for Food, Environmental and Occupational Health and Safety (ANSES), Maisons-Alfort, 94700, France.
高度的海鲜消费可能会导致甲基的积累,造成健康风险. 这项研究引入了终身暴露模型,揭示了法国消费者超过安全限值的潜在风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 风险评估 风险评估
背景情况:
- 海鲜是甲基 (MeHg) 暴露的主要来源.
- 积累的MeHg会造成神经发育和毒性风险,特别是在大量食用海鲜的人群中.
- 目前的风险评估往往忽视了终身暴露动态和MeHg生物积累.
研究的目的:
- 开发和验证一种方法来描述基于终身身体负担的MeHg风险.
- 为了准确的风险评估,将饮食暴露轨迹与基于生理的动力学 (PBK) 模型相结合.
主要方法:
- 使用总饮食研究数据,为代表性法国人口构建了终身饮食暴露轨迹.
- 采用PBK模型,根据饮食摄入量估计MeHg命运和身体负荷轨迹.
- 模拟的头发度与人类生物监测数据进行比较.
主要成果:
- 模拟的头发含量与现有的法国生物监测数据保持一致.
- 确定了MeHg度超过JECFA指导值2.5μg/g的生命阶段.
- 证明了终身暴露建模和PBK衍生生物标志物的风险表征的实用性.
结论:
- 终身暴露评估和PBK建模提供了对MeHg风险的更全面的了解.
- 在某些生命阶段,高海鲜消费者可能面临超过已确定的安全门的风险.
- 这种方法对于评估体内物质积累的风险是有价值的.
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