针对近视进展 (LAMP) 的低度氨酸的五年临床试验研究:第四阶段报告
Xiu Juan Zhang1, Yuzhou Zhang2, Benjamin H K Yip3
1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong; Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China.
Ophthalmology
|March 17, 2024
概括
持续低度的阿特罗宾在5年内有效控制近视. 大多数儿童在停止治疗后需要重新治疗,重新开始0.05%的类药物显示出与持续治疗相似的疗效.
科学领域:
- 眼科医生 眼科 眼科
- 儿科光学测量 儿科光学测量
- 近视控制研究近视研究
背景情况:
- 针对近视进展的低度阿特罗平 (LAMP) 研究调查了阿特罗平的疗效.
- 这项扩展试验评估了长期结果和再治疗策略.
研究的目的:
- 为了评估低度类素对近视控制的5年疗效.
- 为了确定影响再治疗需求的速度和因素.
- 为了评估用0.05%的氨酸进行预先治疗 (PRN) 重复治疗的有效性.
主要方法:
- 这是一项为期5年的随机化,双面膜扩展试验,涉及4至12岁儿童.
- 参与者被随机分配到继续治疗或在第三年停止治疗,随后切换到0.05%的氨酸或PRN重复治疗.
- 概括估计方程分析了球体等价值 (SE) 和轴长 (AL) 的变化.
主要成果:
- 在5年内,累计平均SE进展率最低,持续0.05%的阿特罗平 (-1.34 D).
- 轴长度延长也显示了类似的趋势,有利于更高的度.
- 在PRN组中,87.9%的儿童需要重新治疗,其疗效与3-5岁继续治疗组的疗效相似.
结论:
- 持续使用0.05%的阿特罗宾在5年内显示出近视控制的持续有效性.
- 很大一部分儿童在停止治疗后需要重新治疗,重新开始0.05%的氨酸是有效的.
- 在停止治疗后,考虑重新治疗近视进展.
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