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用EpOME/DiHOME解决昆虫免疫系统,并通过它们的类似物对其进行失调,从而导致病原体过敏

Md Tafim Hossain Hrithik¹, Niayesh Shahmohammadi¹, Gahyeon Jin¹

¹Department of Plant Medicals, Andong National University, Andong, 36729, South Korea.

Insect biochemistry and molecular biology

|March 17, 2024

概括

氧十甲胺酸 (EpOMEs) 在感染后解决了昆虫的免疫反应. 可溶性环氧化酶 (sEH) 抑制剂阻断了这种分辨率,增加了病原体的毒性,这表明EpOME/DiHOME调节了免疫力.

科学领域:

昆虫免疫学昆虫免疫学
生物化学生化学
分子生物学分子生物学

背景情况:

昆虫的免疫反应涉及复杂的信号通路来对抗病原体.
多不和脂肪酸 (PUFA) 衍生物是已知的免疫调解剂,但它们在免疫解决中的作用尚不清楚.
在感染阶段,Spodoptera exigua表现出明显的PUFA概况.

研究的目的:

调查C18PUFA衍生物,特别是环氧十甲胺酸 (EpOMEs) 在解决昆虫免疫反应中的作用.
阐明EpOME作用的机制及其通过可溶性环氧化酶 (sEH) 的调节.
评估调节EpOME/sEH通路对昆虫免疫力和对病原体敏感性的影响.

主要方法:

在感染期间对Spodoptera exigua中PUFA概况的分析.
用EPOMEs和sEH抑制剂进行治疗.
对免疫反应标志物和细菌毒性 (Bacillus thuringiensis) 的评估.

主要成果:

在感染晚期阶段,EPOMEs被确定为免疫解决的关键参与者.
二氧化八甲单酸盐 (DiHOMEs) 是水解的,不活跃的EpOMEs形式,由SEH催化.
sEH抑制模仿了EpOME的免疫抑制作用,并增加了细菌的毒性.

结论:

EpOMEs作为昆虫免疫反应的负调节剂,防止过度炎症.
由sEH调节的EpOME/DiHOME通路对于昆虫的及时免疫解决至关重要.
准sEH可能为控制昆虫-病原体相互作用提供新的策略.

关键词:

迪霍姆 (DiHOME) 是一个这就是EpOME的EpOME.这是天生的免疫力.昆虫昆虫是一种昆虫.氧利平素是一种氧化素.决议决议决议

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