相关实验视频

Updated: Jun 30, 2025

Preparation of Fungal and Plant Materials for Structural Elucidation Using Dynamic Nuclear Polarization Solid-State NMR

Preparation of Fungal and Plant Materials for Structural Elucidation Using Dynamic Nuclear Polarization Solid-State NMR

Published on: February 12, 2019

通过调节Nrf2-介导的抗氧化反应,了解多糖的分子机制,结构-活性关系和应用前景

Nuo Chen¹, Meifen Hu¹, Tingyue Jiang¹

¹Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.

Carbohydrate polymers

|March 17, 2024

概括

多糖类激活Keap1/Nrf2/ARE通路,以对抗氧化应激. 这项研究探讨了抗氧化剂应用的途径交叉和多糖体结构-活性关系.

科学领域:

生物化学和分子生物学
药理学药理学是指药理学的学科.
食品科学食品科学食品科学

背景情况:

氧化应激与许多疾病有关.
Nrf2 (核因子红色素2相关因子2) 是细胞抗氧化反应的关键调节者.
众所周知,多糖类具有抗氧化作用,主要通过Keap1/Nrf2/ARE通路.

研究的目的:

研究Keap1/Nrf2/ARE通路与参与多糖介导抗氧化作用的其他信号通路之间的复杂交叉.
为了阐明多糖的结构-活性关系,关于它们的抗氧化特性.
为设计新型多糖类作为Nrf2-依赖抗氧化反应的调节剂提供基础.

主要方法:

通过主要成分分析和集群分析,系统地阐明多糖的结构-活性关系.
调查Keap1/Nrf2/ARE和其他抗氧化剂信号通路之间的交叉.
关于抗氧化剂多糖的现有文献的综述.

主要成果:

多糖类激活Keap1/Nrf2/ARE通路,促进Nrf2的核转移,并提高抗氧化酶的调节.
在Keap1/Nrf2/ARE和其他通路 (例如PI3K/Akt/GSK3β,JNK/Nrf2,NF-κB) 之间存在复杂的交叉通路,影响Nrf2核转位.
多糖的结构特征 (分子量,单糖组成,糖链) 显著影响其抗氧化活性.

结论:

了解路径交叉提供了开发聚糖基抗氧化剂的新策略,这些抗氧化剂针对Nrf2.
对结构-活性关系的系统分析对于选和设计有效的抗氧化多糖质至关重要.
抗氧化多糖具有广泛的应用在食品,动物生产,化品和生物材料.

关键词:

抗氧化剂多糖类是抗氧化剂.应用程序应用程序计量分析方法计量分析方法分子机制的分子机制 Nrf2 没有任何问题.结构与活动之间的关系.

更多相关视频

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

相关概念视频

Cellulose and Pectic Polysaccharides

Cellulose and Pectic Polysaccharides

Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...

Oligosaccharide Assembly

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

Protein Folding Quality Check in the RER

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...