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Updated: Jun 30, 2025

Green and Low-cost Production of Thermally Stable and Carboxylated Cellulose Nanocrystals and Nanofibrils Using Highly Recyclable Dicarboxylic Acids
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针线:在纤维素酸 ω - 碳酸酸中实现简单性和性能,用于无形固体分散

Stella P Petrova1, Mennatallah A Mohamed2, Huiming Wu3

  • 1Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, United States of America; Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, VA 24061, United States of America.

Carbohydrate polymers
|March 17, 2024
PubMed
概括

研究人员开发了一种新的,可扩展的方法,用于为无形固体分散 (ASD) 制造纤维素聚合物. 这些新型聚合物提高了可溶性和生物可用性,可溶性较差的药物,如felodipine.

关键词:
无形固体分散聚合物纤维素 Ester 是一种纤维素.循环无水化物 循环无水化物药物输送是药物输送的过程.费洛迪平因 (Felodipine) 是一种药物.凝化是一种凝化.

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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