对于神经细胞表面和神经突触蛋白的抗体在神经瘤神经综合征中
1Department of Clinical Neurological Sciences, Western University, London Health Sciences Centre, London, ON, Canada; Department of Pathology and Laboratory Medicine, Western University, London Health Sciences Centre, London, ON, Canada.
Handbook of clinical neurology
|March 17, 2024
概括
麻性神经综合征 (PNS) 涉及针对神经抗原的抗体. 最近的发现表明,细胞外点通常是致病的,并且对免疫疗法有很好的反应,改善了预后.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 从历史上看,神经瘤神经综合征 (PNS) 侧重于细胞内神经抗体,通常与免疫疗法反应和预后不佳有关.
- 这些细胞内抗体被认为是免疫介导的神经损伤的非致病标志物.
结论:
- 细胞外神经抗体在理解和管理PNS方面取得了重大进展.
- 以更新的诊断标准为指导的及时免疫疗法可以改善PNS患者具有细胞外抗体的结果.
- 需要对这些抗体的机制和临床影响进行进一步的研究.
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