从结构化电子健康记录中对哺乳期信息进行表征和验证,用于制药流行病学研究
Hibo H Mohamed1, Kirsten Ehresmann2, Elisabeth M Seburg2
1Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Paediatric and perinatal epidemiology
|March 17, 2024
概括
电子健康记录 (EHR) 准确地捕获母乳养数据,用于研究. 这项研究发现,EHR数据可靠地反映了母乳养状态的母亲报告,显示了高灵敏度和母乳养信息的积极预测值.
科学领域:
- 生殖健康 生殖健康
- 公共卫生信息学 公共卫生信息学
- 临床数据研究 临床数据研究
背景情况:
- 电子健康记录 (EHR) 越来越多地用于药物流行病学研究.
- 然而,EHR中的母乳养数据主要用于临床护理,而不是研究目的.
- 这凸显了需要评估这些数据的质量和研究的有用性.
研究的目的:
- 在婴儿和产后护理期间,在结构化的电子健康记录字段中记录的母乳养信息的特征.
- 为了评估母乳养状态的准确性,与母亲的自我报告相比,从EHR数据中得出的乳房状态.
- 评估EHR数据的有效性,用于研究母乳养实践.
主要方法:
- 评估了211名参与母乳成分研究的患者在结构化EHR领域的母乳养数据.
- 收集了2014-2017年的数据,重点关注12个月以下的婴儿.
- 将EHR哺乳状态与1个月和6个月研究访问的母亲报告进行比较,使用母亲报告作为参考标准.
主要成果:
- 关于母乳养的信息最常见在早期的几周和周围的婴儿访问,每名婴儿的中位数为6条记录.
- 母亲报告显示,93.8%的母乳养和80.1%的6个月的纯母乳养.
- 电子健康数据显示高灵敏度 (近100%永远母乳养,98.0%永远纯母乳养) 和积极预测值 (99.5%任何母乳养,95.0%纯母乳养).
结论:
- 在EHR中的结构化母乳养数据可以准确地分类哺乳状态.
- 这些发现支持对乳房健康数据在母乳养研究中的潜在使用.
- 建议在哺乳率较低的人群中进一步验证.
相关概念视频
Analysis of Population Pharmacokinetic Data
254
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
254
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
126
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
126
Pharmacovigilance
830
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
830
Methods of Documentation VII: EMR
832
Electronic Medical Records (EMRs) primarily center around electronically documenting patients' health information within a single healthcare organization or practice. They contain essential clinical data related to a patient's medical history, diagnoses, medications, treatment plans, lab results, and other pertinent information relevant to the specific encounter or episode of care. EMRs are designed to streamline documentation and workflow processes within individual healthcare...
832
Data Validation
5.0K
Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
Nursing assessment guides are generally based on holistic models rather than medical...
5.0K
Model Approaches for Pharmacokinetic Data: Physiological Models
43
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
43


