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Updated: Jun 30, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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对elexacaftor,tezacaftor和ivacaftor的最低度和AUC之间的相关性

Steffie E M Vonk1, Josje Altenburg2, Ron A A Mathôt1

  • 1Amsterdam UMC location University of Amsterdam, Department of Hospital Pharmacy & Clinical Pharmacology, Meibergdreef 9, Amsterdam, the Netherlands.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
|March 17, 2024
PubMed
概括

在囊性纤维化患者中,可以简化对elexacaftor,tezacaftor,ivacaftor (ETI) 的治疗药物监测. 测量低谷 (Cmin) 值,而不仅仅是曲线下的面积 (AUC),有效地与药物暴露相关.

关键词:
在曲线下面的面积.在CFTR调节器.埃尔克萨卡夫托尔-特萨卡夫托尔-伊瓦卡夫托尔治疗药物监测 治疗药物监测低谷度是最低的度.

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