强大的YKL-40表达在结直肠癌的侵入性瘤前面-A试点研究
Maria Kazakova1, Tsvetomira Ivanova1, Dorian Dikov2
1Department of Medical Biology, Medical University- Plovdiv, Plovdiv, 4000, Bulgaria.
Heliyon
|March 18, 2024
概括
胆酶-3样蛋白1 (YKL-40) 在结直肠癌 (CRC) 组织中升高,特别是在瘤入侵前线和瘤芽内. 这一发现表明YKL-40和瘤芽可能会改善CRC预后预测.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 生物标志物研究 生物标志物研究
背景情况:
- 晚期结肠直肠癌 (CRC) 诊断与患者预后不佳相关.
- 瘤芽,一种形态特征,是CRC的潜在预后因素,但缺乏例行报告.
- 基因酶-3样蛋白1 (CHI3L1),也称为YKL-40,是CRC的候选生物标志物和治疗点.
研究的目的:
- 为了研究YKL-40在结直肠癌中的组织局部化.
- 检查YKL-40表达,瘤芽和CRC中的临床病理参数之间的关系.
主要方法:
- 在31名CRC患者和正常结肠组织中对YKL-40表达的免疫组合化学评估.
- 在CRC样本中评估瘤芽.
- 多色素相关性分析,以评估YKL-40水平,瘤芽和临床病理参数之间的关系.
主要成果:
- 与正常结肠粘膜相比,在CRC组织中观察到显著更高的YKL-40表达.
- 强烈的YKL-40染色在瘤入侵前线局部化.
- 在入侵前线的瘤芽中检测到高YKL-40表达.
结论:
- YKL-40在结直肠癌中表达高,在侵袭边缘和瘤芽内具有特定的局部化.
- 结合YKL-40表达和瘤芽的结合可能成为CRC分层的有价值的预后生物标志物.
- 需要进一步的研究来验证YKL-40和瘤芽作为CRC治疗的预测生物标志物.
更多相关视频
09:28Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
10.1K
07:59Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
Published on: September 3, 2021
6.4K
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...