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相关概念视频

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

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In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
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Cardiovascular System Abnormal Findings II: Auscultation01:25

Cardiovascular System Abnormal Findings II: Auscultation

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Auscultation, an essential part of a heart examination, is done using a stethoscope. It provides crucial information about heart function and possible heart problems. Due to heart problems, abnormal sounds can be heard during systole or diastole. These sounds include S3 and S4 gallops, opening snaps, systolic clicks, and murmurs.
Abnormal Heart Sounds
Gallops:
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Pulse01:16

Pulse

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When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
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Imbalances in Cardiac Output01:26

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
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相关实验视频

Updated: Jun 30, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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在HFpEF中,大动脉流量异常.

Zia Mehmood1, Hosamadin Assadi1,2, Rui Li1,2

  • 1Department of Cardiology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, Norfolk, NR4 7UY, UK.

Wellcome open research
|March 18, 2024
PubMed
概括
此摘要是机器生成的。

心力衰竭和保留射出分数 (HFpEF) 患者表现出显著扰乱的大动脉流动,由平均静脉大动脉流量位移 (FDsavg) 和静脉流量逆转比率 (sFRR) 的升高表明. 这些发现突显了HFpEF中关键的血液动力学变化.

关键词:
大动脉的流动.心脏输出量是指心脏的输出量.HFpEF HFpEF 的意思是什么血液动力学 血液动力学磁共振成像是一种磁共振成像技术.

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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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相关实验视频

Last Updated: Jun 30, 2025

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科学领域:

  • 心血管生理学心血管生理学
  • 医疗成像医学成像
  • 血液动力学 血液动力学

背景情况:

  • 动荡的大动脉流动会损害心血管效率.
  • 心力衰竭与保留射出分数 (HFpEF) 对大动脉流动力学的影响在很大程度上仍未被描述.
  • 研究大动脉流动障碍对于理解HFpEF病理生理学至关重要.

研究的目的:

  • 在患有HFpEF的患者中调查大动脉流动障碍的高级标志物.
  • 为了比较HFpEF患者和健康对照者之间的大动脉流动血液动力学.
  • 为了确定特定的流量参数,表明HFpEF.

主要方法:

  • 一项用四维流动心血管磁共振成像 (4D Flow CMR) 进行的病例控制观察研究.
  • 在管结处分析二维相对比数据,测量平均静脉动脉流位移 (FDsavg),静脉流逆转率 (sFRR) 和脉冲波速度 (PWV).
  • 对年轻健康对照 (HCs),老HCs和HFpEF患者进行比较,对老HCs与年龄性别匹配的HFpEF进行亚组分析.

主要成果:

  • 与旧的HC相比,HFpEF患者的FDsavg (23±10%对16±5%,P<0.001) 和sFRR (11±10%对7±6%,P<0.001) 显著更高.
  • 对于FDsavg (>17.7%) 和sFRR (>7.3%) 的特定值,在区分HFpEF与旧HC时,显示出显著的灵敏度和特异性.
  • 亚组分析证实HFpEF患者的FDsavg和sFRR升高,特定的切断值达到高灵敏度和特异性.

结论:

  • 大动脉流血动力学,特别是FDsavg和sFRR,在老化和HFpEF患者中发生显著变化.
  • 这些先进的流量标记可以帮助区分HFpEF患者和健康个体.
  • 这些发现强调了大动脉流动障碍在HFpEF病理生理学中的作用.