Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cationic nanotrap curbs UVB-induced cutaneous photodamage via exosomal cfNA capture.

Biomaterials·2026
Same author

Multiomic insights into fungal polylactic acid degradation: Metabolic adaptation and hydrolytic mechanisms of Sporobolomyces pararoseus.

Journal of proteomics·2026
Same author

Intermittent Fasting Attenuates Cognitive Decline in D-Galactose-Induced Aging Rats in Association with β-Hydroxybutyrate and PI3K/AKT/GSK-3β Signaling.

Neurochemical research·2026
Same author

Universal primer-based RPA combined with parallel CRISPR/Cas12a decoding for rapid multi-species meat authentication.

Food chemistry·2026
Same author

Identifying unknown contributors to two-person DNA mixtures via whole-genome sequencing.

Forensic science international. Genetics·2026
Same author

Bifunctional trehalase FsTreA coordinates intracellular mobilization and extracellular utilization of trehalose to modulate virulence in <i>Fusarium sacchari</i>.

Applied and environmental microbiology·2026

相关实验视频

Updated: Jun 30, 2025

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

17.4K

使用内源性标记物进行单细胞血统追踪.

Yan Xue1,2, Zezhuo Su1,2,3, Xinyi Lin1

  • 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Biophysical reviews
|March 18, 2024
PubMed
概括

细胞谱系追踪使用体质突变作为DNA条形码来了解发育和疾病. 进步使人类的单细胞分解成为可能,揭示了发育和瘤进化过程中的细胞关系.

关键词:
线粒体突变的突变单细胞血统的追踪 单细胞血统的追踪身体核突变是人体核突变.空间的克隆进化.

更多相关视频

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

3.0K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

10.7K

相关实验视频

Last Updated: Jun 30, 2025

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

17.4K
Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

3.0K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

10.7K

科学领域:

  • 遗传学 遗传学 是一个
  • 发展生物学 发展生物学
  • 基因组学就是基因组学.

背景情况:

  • 了解细胞命运和关系对于发育和疾病研究至关重要.
  • 身体突变作为内源性DNA条形码用于谱系追踪.
  • 最近的进展允许单细胞分辨率用于模型生物和人类的谱系追踪.

研究的目的:

  • 审查实验和计算技术用于细胞谱系追踪使用体质突变.
  • 讨论这些方法的优点和挑战.
  • 探索血统追踪在发育和瘤进化中的应用.

主要方法:

  • 利用自然发生的体质核和线粒体突变.
  • 应用单细胞分辨率技术.
  • 采用计算方法进行数据分析.

主要成果:

  • 身体突变为破译细胞关系提供了内源性遗传标记.
  • 单细胞血统追踪提供了对发育过程的洞察力.
  • 对空间克隆进化的分析有助于理解瘤进展.

结论:

  • 随着体质突变的细胞谱系追踪是研究发育和疾病的强大工具.
  • 整合实验和计算方法可以增强血统追踪能力.
  • 未来的研究可以利用这些技术来获得更深入的生物学见解.