局部高级口腔状细胞癌:审计和结果评估
Rathindra Nath Bera1, Richik Tripathi2, Sapna Tandon3
1Department of Oral and Maxillofacial Surgery, Dental College Rajendra Institute of Medical Sciences Ranchi, Ranchi, India.
概括
局部发达的口腔状细胞癌 (OSCC) 的生存率是由外囊扩散,骨/皮肤参与和淋巴结大小预测的. 前部手术是可切除OSCC的标准;诱导化疗可能有助于不可切除的病例.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 在印度,口腔状细胞癌 (OSCC) 经常呈现于晚期 (III/IV).
- 局部晚期OSCC (LAOSCC) 的管理需要评估治疗方法和生存结果.
- 对LAOSCC在一个研究所管理的案件进行了回顾性分析.
研究的目的:
- 审查LAOSCC.的治疗策略.
- 评估生存数据并确定影响LAOSCC患者生存的因素.
- 为了比较可切除和不可切除LAOSCC的不同治疗方法的结果.
主要方法:
- 追溯性研究设计.
- 卡普兰-梅尔总生存率 (OS) 和无病生存率 (DFS) 分析方法.
- 记录等级测试和考克斯回归 (单变量/多变量) 用于生存因子的识别.
主要成果:
- 中位数的生存期为32个月,中位数的DFS为24个月.
- 在T4b患者的OS/DFS中没有显著的差异,这些患者接受了前期手术,而不是手术后的诱导化疗.
- 囊外扩散,骨干干涉,皮肤透,手术边缘和淋巴结大小是关键的生存预测因素.
结论:
- 前部手术是可切除LAOSCC的标准护理.
- 诱导化疗可以改善技术上无法切除的OSCC的切除能力.
- 对于不可切割的LAOSCC.而言,并发化疗,顺序化疗和激进放射治疗之间没有观察到显著的生存差异.
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