:

Daoming Lyu1,2, Xingbo Wang1,2, Yong Chen3

  • 1Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, New York, NY, USA.

iScience
|March 18, 2024
PubMed
概括

大型语言模型 (LLM) 为生物医学研究提供了强大的AI能力. 本文审查了它们的使用,挑战和未来的研究方向,重点是医疗保健应用中的可解释性.

相关概念视频

Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
10.3K