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Updated: Jul 27, 2026

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从免疫缺陷患者中分离出的Bcl11bN797K变体抑制了小鼠早期的胸细胞发育

Kazuaki Matsumoto1,2, Kazuki Okuyama1, Tom Sidwell3

  • 1Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama Kanagawa, Japan.

Frontiers in immunology
|March 18, 2024
PubMed
概括

转录因子BCL11B对于T细胞发育至关重要. 一种BCL11BN807K变异的小鼠模型揭示了它在胸细胞过渡和免疫细胞发育中的重要作用.

关键词:
在 BCL11B 中.这是IEISIEIS.一个T细胞细胞.免疫缺陷 免疫缺陷 免疫缺陷错误的意义的变体.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...