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晚发扩展性心肌病在自身免疫介导的完整先天性心脏阻塞:一个案例报告

Amulya Dharmagadda¹, Sampada Tambolkar¹, Sanjay Chavan¹

¹Pediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.

|March 18, 2024

概括

婴儿的自身免疫性先天性心脏阻塞 (CHB) 可能导致扩张性心肌病. 早期识别和管理对于改善受影响儿童的结果至关重要.

科学领域:

儿童心脏病学儿童心脏病学
免疫学免疫学免疫学
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

完全先天性心脏阻塞 (CHB) 是一种罕见的,严重的小儿节律失常症,通常是由于胎盘母体抗体而引起的自身免疫性起源.
隔离的CHB与结构正常的心脏表明母亲的自身抗体影响胎儿的心脏导电.
并发症包括扩张性心肌病 (DCM),心律失常和纤维筋疲劳症,DCM是关键的预后因素.

研究的目的:

在婴儿中呈现自身免疫性先天性心脏阻塞 (CHB) 病例,呈现为扩张性心肌病 (DCM).
要突出母亲的Sjogren综合征和胎儿的CHB与DCM之间的联系.
讨论CHB相关DCM的预后影响和管理策略.

主要方法:

一个患有DCM的1岁女婴的回顾性病例审查.
评估母亲自身免疫病史,包括Sjogren综合征和抗RO抗体标位.
临床评估和婴儿心脏状况的管理.

主要成果:

婴儿出现了DCM,并被追溯诊断为自身免疫性CHB.
这位母亲患有Sjogren综合征,抗RO抗体呈阳性.
孩子在没有节奏的情况下保持无症状一年,并通过医疗治疗稳定.

结论:

自身免疫性CHB可以在婴儿中表现为DCM,这强调了考虑这种病因的重要性.
母亲自身免疫抗体,如抗RO,与胎儿的CHB和随后的DCM有关.
在CHB病例中迅速识别DCM对于预后评估和潜在的早期节奏干预至关重要.

关键词:

心血管阻塞心血管阻塞生产性心脏阻塞是一种先天性心脏阻塞.扩张性心肌病症扩张性心肌病症儿科医生和新生儿科这是Sjogren的.

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