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在COVID-19患者的急性呼吸衰竭中,与同时使用抗凝剂一起使用tenecteplase:一个随机对照试验
Hooman Poor1, Kurt Yaeger2, Serina Deeba2
1Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
Cureus
|March 18, 2024
概括
测试中的一种血栓缓解剂,可改善COVID-19急性呼吸衰竭患者的治疗结果. 这项试验显示了对存活率和减少功能衰竭的潜在益处,尽管需要进行更大规模的研究.
科学领域:
- 肺部医学 肺部医学
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肺栓塞和血栓栓塞是COVID-19急性呼吸衰竭的关键因素.
- 在这种情况下,用基酶进行血栓溶解的疗效仍未得到研究.
研究的目的:
- 评估基对COVID-19急性呼吸衰竭患者结果的影响.
主要方法:
- 进行了一项随机对照的双盲II期试验 (NCT04505592).
- 患有COVID-19急性呼吸衰竭的患者被随机分为2:1接受甲 (0.25 mg/kg) 或安慰剂,两组患者接受治疗性肝素至少72小时.
主要成果:
- 纳入了13名患者:8名在基剂组和5名在安慰剂组.
- 在28天后,63%的基酶组活着,没有呼吸衰竭,而安慰剂组的40% (p=0.43).
- 功能衰竭发生在0%,与60%的安慰剂组 (p=0.07) 较,在tenecteplase组发生. 大幅出血发生在25%的烯酸甲组和20%的安慰剂组.
结论:
- 与肝素相结合的甲显示,有可能改善COVID-19呼吸衰竭的结果.
- 这项研究受到小样本规模的限制,需要进行更大规模的确认试验.
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