在绵羊中逃避表观遗传重编程的基因组区域的表征
Camila U Braz1, Matilde Maria Passamonti2, Hasan Khatib3
1Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Environmental epigenetics
|March 18, 2024
概括
环境诱导的表观遗传标记可以逃避羊的重编程,影响后代的发育和健康. 这些在DNA甲基化中的遗传性变化突显了大脑疾病和不孕不育之间的潜在联系.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 基因组学就是基因组学.
- 发展生物学 发展生物学
背景情况:
- 哺乳动物的基因组在生殖细胞和胚胎发育过程中经历表观遗传重编程.
- DNA甲基化标记被删除并重新建立,但印记的基因和可移植元素 (TE) 保留甲基化.
- 对于环境诱导的表观遗传标记存在有限的理解,这些标记在非模型物种中逃脱了重编程.
研究的目的:
- 研究在绵羊中逃避表观遗传重编程的基因组区域.
- 描述基因在这些区域内的位置和功能.
- 探索环境诱导的标记的跨代表观遗传.
主要方法:
- 在绵羊中对跨代遗传的差异甲基化细胞因子 (DMCs) 的分析.
- 在可移植元素 (TE),印记基因和其他基因组区域中识别DMC.
- 评估与DMCs逃脱重编程相关的基因功能.
主要成果:
- 鉴定了107种跨代的DMCs作为对绵羊的父亲饮食的反应.
- 基因组区域,而不仅仅是TE或印记基因,表现出逃脱重编程的倾向.
- 34个脱离重编程的甲基基因影响了生长,发育,生育和神经发育,其中21个与大脑疾病有关.
结论:
- 基因组区域可以逃避表观遗传重编程,作为跨代表观遗传候选人.
- 父亲营养诱导的表观遗传标记可以在绵羊中跨代传播.
- 影响神经发育的基因与与不孕症相关的基因之间存在潜在的重叠.
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