在健康的老年人中重新评估高高的HDL胆固醇水平,作为各种疾病状态的风险因素
1The School of International Medical Technology of Shanghai Sanda University Shanghai 201209, China.
American journal of clinical and experimental immunology
|March 18, 2024
概括
高密度脂蛋白胆固醇 (HDL-C) 的高水平可能会增加老年人的健康风险,包括骨折和痴呆症. 对于老年人来说,目前对HDL胆固醇益处的理解需要修订.
科学领域:
- 老年学是一门学科.
- 心血管科学 心血管科学
- 生物化学 生化学
背景情况:
- 高密度脂蛋白胆固醇 (HDL-C) 传统上被认为可以预防心血管疾病.
- 普遍的HDL-C益处的既定观点正在重新评估,特别是在老龄化人口中.
研究的目的:
- 为了审查HDL-C在老年人中的作用.
- 质疑老年人中高密度胆固醇对健康的普遍益处的假设.
主要方法:
- 基于人口的大型研究的分析,包括ASPREE试验和英国生物银行.
- 审查现有的关于高质量血糖和老年人的健康结果的文献.
主要成果:
- 高水平的HDL-C与老年人骨折,痴呆和心血管疾病的风险增加有关.
- 这些关联在老年男性中显得更加明显.
- 潜在的机制包括胆固醇结晶和HDL粒子功能受损.
结论:
- 了解HDL-C在老年人中的作用需要改进.
- 对老年人群的临床指南和风险评估策略可能需要对HDL-C水平进行调整.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
156
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
156
Cholesterol: Significance and Regulation
544
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
544
Lipids: Dietary Sources and Requirements
732
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
732
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
81
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
81
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
660
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
660
Assessment of the Cardiovascular System I: Subjective Data
328
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
328


