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Updated: Jun 30, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Published on: July 17, 2020

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通过降解 PTPN14,HPV18 E7 抑制了 LATS1 激酶,并通过降解 PTPN14 来激活 YAP1

William J Blakely1, Joshua Hatterschide1,2, Elizabeth A White1

  • 1Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

bioRxiv : the preprint server for biology
|March 18, 2024
PubMed
概括

高风险的人类乳头瘤病毒 (HPV) E7瘤蛋白降解PTPN14,减少Hippo通路活动. 这促进了YAP1的激活,抑制了角质细胞的分化,并导致癌症的发展.

关键词:
生物科学 生物科学河马河马是什么意思 海马河马是什么意思人类乳头瘤病毒 人类乳头瘤病毒微生物学 微生物学PTPN14 PTPN14 在线观看一个YAP1一个YAP1不同化的差异化差异化.质细胞 (keratinocyte) 是一种细胞.这是一种瘤抑制剂.

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