相关实验视频

Updated: Jun 30, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

7.3K

改进了使用SEEKR进行非线性序列比较的功能

Shuang Li, Quinn Eberhard, Luke Ni

    bioRxiv : the preprint server for biology
    |March 18, 2024
    PubMed
    概括

    通过k-mer表示 (SEEKR) 的序列评估现在估计了序列相似性的统计意义. 新的SEEKR函数识别长非编码RNA (lncRNA) 中的XIST样片段,并支持RNA-Seq数据使用.

    更多相关视频

    Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group07:49

    Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

    Published on: August 16, 2017

    7.1K
    G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome06:40

    G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

    Published on: March 22, 2018

    5.8K

    相关概念视频

    Evolutionary Relationships through Genome Comparisons02:54

    Evolutionary Relationships through Genome Comparisons

    Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
    5.7K
    Multiple Comparison Tests01:13

    Multiple Comparison Tests

    Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
    It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
    3.9K
    Leaky Scanning02:28

    Leaky Scanning

    During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
    5.1K
    RNA-seq03:21

    RNA-seq

    RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
    Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
    10.0K
    Wilcoxon Signed-Ranks Test for Matched Pairs01:09

    Wilcoxon Signed-Ranks Test for Matched Pairs

    The Wilcoxon signed-rank test for matched pairs evaluates the null hypothesis by combining the ranks of differences with their signs. It essentially tests whether the median of the differences in a population of matched pairs is zero. Since the test incorporates more information than the sign test, it generally yields more trustable conclusions. This test also does not require the data to follow a normal distribution, but two conditions must be met for it to be applicable: (1) the data must...
    123
    Next-generation Sequencing03:00

    Next-generation Sequencing

    The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
    Next-Generation Sequencing Methods
    Although all next-generation methods use different technologies, they all share a set of standard features....
    88.8K