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Updated: Jun 30, 2025

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选择BOIN设计参数p.tox是否仅取决于目标DLT速率?

Rong Lu1

  • 1The Quantitative Sciences Unit, Division of Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, California.

medRxiv : the preprint server for health sciences
|March 18, 2024
PubMed
概括

贝叶斯最佳间隔 (BOIN) 设计对于确定药物的最大耐受剂量 (MTD) 是有效的. 然而,默认参数p.tox可能并不总是最佳的,替代值可以在剂量确定研究中产生类似的结果.

关键词:
贝叶斯的最佳间隔设计.R 包装BOIN BOIN 包装BOIN 包装确定剂量的方法.

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