怀孕期间的西方饮食模式与儿童和青少年的神经发育障碍有关
medRxiv : the preprint server for health sciences
|March 18, 2024
概括
怀孕期间的西方饮食与儿童注意力缺陷/多动障碍 (ADHD) 和自闭症的风险更高有关. 早产前营养可能是预防这些神经发育障碍的关键.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 神经发育障碍 (NDD) 很普遍,但孕妇在怀孕期间饮食的影响仍未得到充分研究.
- 关于产前营养在儿童神经发育中的作用,存在重大知识差距.
研究的目的:
- 研究怀孕期间母亲饮食模式与后代神经发育障碍之间的关联.
- 确定特定的饮食模式及其与ADHD和自闭症等疾病的相关性.
主要方法:
- 一项508名10岁儿童的观察性临床研究,使用自我报告的食物频率问卷来定义饮食模式.
- 在三个独立的母婴队列中验证研究结果.
- 怀孕24周血液代谢组分析以确定介导代谢物并评估ADHD的预测价值.
主要成果:
- 怀孕期间的西方饮食模式与ADHD和自闭症诊断和症状的几率增加显著相关.
- 这些关联在多个大,独立的队列中一致观察到.
- 代谢模型确定了15种因果调解代谢物,增强了ADHD预测,从怀孕早期到怀孕中期明显的影响.
结论:
- 怀孕期间母亲的西方饮食是儿童神经发育障碍的危险因素.
- 怀孕早期的营养起着至关重要的作用,这表明有针对性的产前饮食干预的潜力.
- 这些发现支持制定基于证据的饮食指南,以减轻NDD风险.
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