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Updated: Jun 30, 2025

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

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系统的计算机辅助二硫化物设计作为稳定预注射I类融合蛋白的总体策略

Karen J Gonzalez, Kevin Yim, Jorge Carlos Blanco

    bioRxiv : the preprint server for biology
    |March 18, 2024
    PubMed
    概括

    开发一种计算方法,以稳定病毒融合蛋白在它们的预注液状态下,以改进疫苗设计. 这种方法成功地确定了呼吸道同胞病毒 (RSV) F蛋白的稳定二硫化物,从而导致了一种有前途的疫苗候选人.

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    Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

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    相关概念视频

    Tagging and Fusion Proteins01:24

    Tagging and Fusion Proteins

    Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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