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Updated: Jun 30, 2025

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在皮层发育过程中,MYT1L缺乏会损害刺激神经元的轨迹

Allen Yen1,2, Xuhua Chen1,3, Dominic D Skinner4

  • 1Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.

bioRxiv : the preprint server for biology
|March 18, 2024
PubMed
概括

丧失MYT1L功能会破坏神经元发育和基因表达,影响激发性神经元的比例. 由MYT1L抑制基因调节至关重要,可能是MYT1L综合征的基础.

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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