来自心房患者的中风栓塞,富含中性粒细胞外细胞陷
Sajal Medha K Akkipeddi1, Redi Rahmani1, Derrek Schartz2
1Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA.
Research and practice in thrombosis and haemostasis
|March 18, 2024
概括
急性缺血性中风 (AIS) 患有心房动 (AF) 的患者的栓塞显示出更高水平的中性粒细胞外细胞陷 (NET). 这一发现突显了AF中独特的中风生物学,并表明了AIS潜在的新治疗点.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 急性缺血性中风 (AIS) 栓塞表现出显著的组成异质性.
- 这种异质性可能会影响治疗疗效.
- 了解栓塞的组成对于开发向疗法至关重要.
研究的目的:
- 调查与没有心房动 (AF) 的AIS患者的栓塞物质中的蛋白质差异.
- 为了识别与AF相关的特定蛋白质标志物,在中风emboli.
- 探索观察到的蛋白质组变异的功能影响.
主要方法:
- 使用质谱学对24名AIS患者的血栓栓塞物质进行蛋白质组分析.
- 将蛋白质分为功能组的分类 (例如,红细胞,血小板,中性粒细胞,组织细胞).
- 对AF-阳性 (AF+) 和AF-负 (AF-) 样本之间的蛋白质丰度进行比较分析,然后进行丰富分析.
主要成果:
- 在AF+和AF-样本中,有166种蛋白质的表达差异.
- 中性粒细胞和基因素蛋白在AF+栓塞中显著丰富.
- 基因组丰富分析确定了中性粒细胞外陷 (NETs) 是一个关键组成部分,与中性粒细胞激活和脱粒化相关的途径在AF患者中具有高度意义.
结论:
- 患有AF的患者中风栓塞与NETs进行丰富.
- 网络代表了thrombi.com的一个研究不足的结构组成部分.
- 这一发现表明AF患者的独特中风病理学,并确定了AIS的潜在治疗点.
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