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非向的代谢学揭示了ACE2淘汰赛小鼠的代谢失调和组织敏感性

Lili Zhao¹, Weili Yang¹, Wenyi Ji¹

¹Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

|March 18, 2024

概括

ангиотензин转化酶2 (ACE2) 缺乏导致代谢困扰,影响肝脏和肌肉等关键组织的能量代谢. 这项研究揭示了ACE2淘汰赛小鼠的代谢变化,为代谢障碍提供了洞察力.

科学领域:

代谢学代谢学代谢学
分子生物学分子生物学
内分泌学在内分泌学.

背景情况:

ангиотензин转化酶2 (ACE2) 的多态性与2型糖尿病 (T2DM),肥胖和脂质失调有关.
在ACE2淘汰赛 (ACE2 KO) 小鼠中,能量代谢受损,特别是在高脂肪饮食 (HFD) 条件下.

研究的目的:

调查全球代谢学概况和组织特异性对ACE2缺乏症的反应.
了解肝脏,骨肌肉和 epididymal 白脂肪组织 (eWAT) 在正常和 HFD 条件下如何应对 ACE2 缺失.

主要方法:

不针对性代谢进行了ACE2 KO和野生型 (WT) 常规饮食 (ND) 和HFD小鼠的血清.
代谢分析还对肝脏,骨肌肉和HFD小鼠的eWAT进行了分析.
使用统计和途径分析来确定显著的代谢变化.

主要成果:

与WT相比,在ACE2 KO小鼠中观察到血清和组织代谢的显著变化.
缺乏ACE2导致特定代谢物的变化,包括增加N-phenylacetylglutamine (PAGln) 和减少 lysophosphatidylcholines (LPCs) 和 lysophosphatidylethanolamines (LPEs).
确定了组织特定的代谢途径失调,在ACE2 KO小鼠的多个组织中观察到降低的l-ergothioneine.

结论:

由于ACE2缺乏,导致全身代谢应急.
这些发现为与ACE2变异相关的代谢障碍的发病提供了新的见解.
组织特异性代谢反应突出显示了ACE2在维持代谢平衡中的复杂作用.

关键词:

在ACE2中,ACE2是ACE2.基因淘汰赛基因淘汰赛葡萄糖脂类代谢的代谢代谢学代谢学代谢学这就是T2DM.

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