基于聚乙醇的纳米复合物水凝和碳纳米管用于NIR光触发的药物输送
Karla F García Verdugo1, Brianda M Salazar Salas1, Lerma Hanaiy Chan Chan2
1Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo CP 83000, Mexico.
ACS omega
|March 18, 2024
概括
这项研究引入了一种新型的光热纳米复合材料水凝,用于控制药物释放. 功能化的多壁碳纳米管增强近红外触发释放的水性和水性药物,显示有希望的向癌症治疗.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 光热纳米复合材料水凝提供近红外 (NIR) 辐射触发的远程药物递送.
- 开发具有增强药物释放能力的先进水凝对于向治疗至关重要.
研究的目的:
- 合成和描述一种新的水凝,其中包括功能化的多壁碳纳米管 (MWCNT-f).
- 从纳米复合物水凝中评估NIR触发的水友性 (5-甲) 和疏水性 (易布洛芬) 药物的释放.
- 评估开发材料的体外细胞毒性.
主要方法:
- 通过冷/解方法的水凝合成,使用聚乙醇,聚乙烯甲基以太-高酸和聚乙烯甲基以太).
- 纳入功能化的多壁碳纳米管 (MWCNT-f).
- 使用光谱学,热分析,显微镜,机械测试,膨胀动力学和光热分析进行表征.
- 在被动和NIR照射条件下进行药物加载和释放研究.
- 在癌细胞和非癌细胞的体外细胞毒性测定.
主要成果:
- 添加低MWCNT-f含量 (0.2重量%) 显著改变了水凝的微观结构和物理化学特性.
- 尼尔射线照射显著增加了药物的累积释放量:5-甲的21%和伊布罗芬的39%.
- 装有5-甲的纳米复合水凝显示出对癌细胞的选择性细胞毒性,而不会伤害非癌细胞.
结论:
- 开发的含有MWCNT-f的水凝具有出色的光热性能,可控制药物释放.
- 这种材料有效地促进了对NIR刺激的反应中,水友性和水害性药物的释放.
- 水凝显示出作为针对性癌症治疗的先进药物输送平台的潜力.
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