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在神经性厌食症中静止时减少背部前 - 关节连接

Alexandra F Muratore^1,2, Karin Foerde³, E Caitlin Lloyd^1,2

¹Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Psychological medicine

|March 18, 2024

概括

神经性厌食症患者表现出背部前-上回路中静止状态大脑连接的改变,特别是右前尾-dlPFC合的减少. 这些发现表明,神经性厌食症治疗的潜在神经点.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

神经性厌食症 (AN) 是一种严重的精神疾病,治疗选择有限.
基于AN的神经机制对于开发新型治疗点至关重要.
以前的研究表明,在AN中,背部前-状回路功能障碍,但静止状态异常仍然不清楚.

研究的目的:

为了研究厌食症患者和健康对照者之间背部前-状回路的休息状态功能连接性差异.
要确定在休息期间是否存在前-状网络中观察到的异常,并反映出基本的大脑组织.

主要方法:

结合了四项研究中89名AN患者和92名健康对照的休息状态fMRI数据.
使用ComBat协调来减轻现场影响.
进行了基于种子的功能连接性分析,重点关注前尾和dlPFC,并进行探索性全脑分析,ALFF和节点中心性.

主要成果:

与对照组相比,AN患者的右前尾部-dlPFC连接显著减少 (p=0.002).
右前尾骨和左上/中前回旋之间连接性减少 (p=0.028).
右前尾皮和右皮皮层之间的连接性增加 (p=0.038).

结论:

背部前-腹区域内合的减少表明在神经厌食症中静止时存在持久的基于电路的异常.
鉴定到的前-状网络代表了AN的潜在治疗目标.
休息状态fMRI可以揭示AN的基本大脑组织差异.

关键词:

神经性厌食症是一种神经性厌食症.在前尾前尾部.背部的前额-三角形电路.功能磁力共振成像 (fMRI) 是一种重复的跨脑磁刺激是重复性的.静止状态的功能连接.

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