在儿科轻度创伤性脑损伤后的慢性阶段的执行功能,行为和白质微观结构:来自青少年大脑认知发育研究的结果
Anja K Betz1, Suheyla Cetin-Karayumak2, Elena M Bonke1,3
1cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany.
Psychological medicine
|March 18, 2024
概括
儿童轻度创伤性脑损伤 (mTBI) 在几年后可能会影响执行功能和情绪调节. 这些影响取决于孩子在受伤时的年龄.
科学领域:
- 儿科神经学 儿科神经学
- 神经科学是一个神经科学.
- 发展心理学是发展心理学.
背景情况:
- 轻度创伤性脑损伤 (mTBI) 是一个常见的儿童损伤.
- 儿科mTBI后的长期认知和行为结果尚不清楚.
- 伤害时的年龄对长期结果的影响在很大程度上是未知的.
研究的目的:
- 调查儿科mTBI后的长期认知和行为结果.
- 检查受伤时的年龄对这些结果的影响.
- 用MRI来评估结构性大脑变化.
主要方法:
- 匹配的队列研究将mTBI (n=406) 的儿童与典型发育 (TDC; n=812) 和骨科损伤 (OI; n=812) 的对照进行了比较.
- 评估基于任务和父母的执行功能,情绪调节和冲动性.
- 分析了基于MRI的白质微结构 (FA,MD) 和受伤时的年龄 (0-3,4-7,8-10岁) 的影响.
主要成果:
- 患有mTBI病史的儿童比对照人群表现出更高的父母评级的执行功能障碍,冲动性和较差的自我调节.
- 这些差异与特定的受伤年龄组有关.
- 基于任务的执行功能或小组之间的白质微观结构没有显著差异.
结论:
- 儿科mTBI影响日常执行功能,冲动性和情绪调节伤害后的几年.
- 结果与受伤年龄有关,突出了脆弱的发育时期.
- 白质微观结构在这个队列中没有显示出显著的变化.
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