动物宿主在塑造肠道微生物群变异中的作用
Elisa Maritan1, Andrea Quagliariello1, Enric Frago2
1Department of Comparative Biomedicine and Food Science, University of Padova, 35020 Padova, Italy.
概括
宿主因素显著影响动物微生物组的组成和进化. 本综述综合了当前关于宿主微生物相互作用的知识,突出了对完整理解的研究需求.
科学领域:
- 微生物学 微生物学
- 生态生态学 生态生态学
- 进化生物学 进化生物学
背景情况:
- 与动物相关的微生物群落 (微生物组) 是数百万年来与宿主共同进化的结果.
- 宿主-微生物相互作用是复杂的,受到生态和环境因素的影响,以及宿主特定的动态.
研究的目的:
- 审查和综合当前对宿主因素如何塑造动物微生物组的理解.
- 探索不同动物类别的宿主驱动微生物组动态的保存和变化的方面.
主要方法:
- 文献审查整合基于生态系统的方法,元基因组学和数学建模.
- 对影响微生物组组装和进化的主体因素现有研究的分析.
主要成果:
- 宿主因素被确定为动物物种微生物组合的主要驱动因素.
- 主体因素在多大程度上影响微生物组组和进化轨迹的确切程度仍在调查中.
结论:
- 宿主因素在塑造动物微生物组中发挥着关键作用,在种群中保留和变化的模式.
- 需要进一步的研究和理论进步,才能充分阐明宿主-微生物动态和微生物组进化.
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