感染和变暖的双重压力因素可以破坏宿主微生物组的稳定
J D Li1, Y Y Gao2,3, E J Stevens1
1Department of Biology, University of Oxford, Oxford OX1 2JD, UK.
概括
气候变化和感染影响动物微生物群. 变暖可以缓解感染.
科学领域:
- 微生物组研究的研究.
- 气候变化生物学
- 主体-寄生虫相互作用
背景情况:
- 气候变化导致极端高温和传染病爆发.
- 动物微生物组对于宿主在压力期间的生存和健康至关重要.
- 了解全球变化下的微生物群变化对于预测宿主健康至关重要.
研究的目的:
- 研究温度升温和寄生虫感染如何影响野生微生物群.
- 确定生物 (感染) 和非生物 (变暖) 因素对微生物组结构的综合影响.
- 评估微生物组变化与宿主微生物群落稳定性之间的关系.
主要方法:
- 对来自不同度的野生Caenorhabditis elegans分离物的分析.
- 暴露于模拟的变暖条件和感染寄生虫Leucobacter musarum.
- 16S rRNA基因测序以表征微生物组合和多样性.
主要成果:
- 随着时间的推移,微生物群的多样性减少,分散增加,特别是在未感染的成年人中.
- 感染Leucobacter musarum会破坏宿主微生物群落的稳定,降低分类统治,增加分散.
- 升温并没有增加感染微生物组的不稳定性;成人前升温减轻了感染的不稳定性影响.
结论:
- 生物和非生物因素相互对抗,形成微生物组结构.
- 增加微生物群分散可能与微生物物种相互作用的变异性降低相关.
- 这些发现提高了对气候变化和流行病条件下的动物微生物组动态的理解.
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