基于药理动力学的儿科剂量评估和优化使用唾液 - 一个案例研究

Marion Anliker-Ort1, Frédérique Rodieux1,2, Victoria C Ziesenitz1,3

  • 1Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.

概括

唾液采样可以通过减少对血样本的需求来简化儿科药理动力学 (PK) 研究. 虽然唾液对甲米醇代谢物的变异性比血更高,但它仍然可以帮助优化儿科药物剂量.

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