循环血管细胞粘附分子-1和细胞间粘附分子-1与长期心脏功能的关联
Daniel T Mathew1, Graham Peigh2, Joao A C Lima3
1Northwestern University Feinberg School of Medicine Chicago IL.
Journal of the American Heart Association
|March 18, 2024
概括
血管细胞粘附分子-1 (VCAM-1) 和细胞间粘附分子-1 (ICAM-1) 与心脏功能降低有关. 这些分子可能会通过损害左心房功能而增加心力衰竭与保留射出分数 (HFpEF) 和心房动 (AF) 风险.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 心脏成像 - - 心脏成像
背景情况:
- VCAM-1和ICAM-1与心脏衰竭与保留喷射分数 (HFpEF) 和心房动 (AF) 相关.
- VCAM-1,ICAM-1和详细的心脏结构/功能测量之间的关系尚不清楚.
- 了解这些关联可能会揭示连接细胞粘附分子到HFpEF和AF的途径.
研究的目的:
- 评估VCAM-1,ICAM-1和心脏结构/功能之间的关联.
- 探索VCAM-1和ICAM-1作为HFpEF和AF风险的潜在媒介.
- 研究左心房 (LA) 应变在这些关系中的作用.
主要方法:
- 利用了多民族动脉样硬化研究 (MESA) 的数据.
- 通过心磁共振成像评估VCAM-1和ICAM-1水平以及心脏结构/功能.
- 进行了多变量调整和调解分析,重点关注LA菌株.
主要成果:
- 较高的VCAM-1和ICAM-1水平与较低的LA峰纵向应变相关.
- 升高的VCAM-1和ICAM-1与更糟糕的全球环周左心室应变有关.
- 没有发现VCAM-1/ICAM-1与左心室心肌痕或间歇性纤维化之间存在关联.
- 较低的LA峰纵向应变介导了8-9%的VCAM-1与HFpEF和AF的关联.
结论:
- 较高的VCAM-1和ICAM-1与LA功能受损和左心室缩功能有关.
- VCAM-1和ICAM-1似乎与心肌痕或间歇性纤维化无关.
- 损坏的LA储功能可能是VCAM-1和ICAM-1对HFpEF和AF风险作出贡献的关键途径.
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