在涉及异常健康事件的美国政府人员及其家属中进行临床,生物标志物和研究测试
Leighton Chan1,2, Mark Hallett3, Chris K Zalewski4
1Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland.
JAMA
|March 18, 2024
概括
与对照组相比,患有异常健康事件 (AHIs) 的人报告疲劳,抑郁和失衡增加. 然而,大多数临床和生物标志物评估没有显示出显著的差异,这表明复杂的AHI呈现.
科学领域:
- 神经学
- 环境健康
- 精神病学
背景情况:
- 自2015年以来,异常健康事件 (AHIs) 涉及到美国政府人员经历不明原因的症状,如头和认知功能障碍.
- 这些事件通常与侵入性声音和头部压力有关, 促使广泛的调查.
研究的目的:
- 将美国政府人员与AHI和匹配的对照参与者之间的临床,研究和生物标志物评估进行比较.
- 确定神经,前庭,听觉,视觉和心理功能以及特定生物标志物的潜在差异.
主要方法:
- 在2018年6月至2022年7月期间,国家卫生研究院临床中心进行了一项探索性研究.
- 八十六名患有AHI的参与者和30名对照参与者接受了全面的临床评估,包括听觉,前庭,平衡,视觉,神经心理和血液生物标志物测试 (GFAP,NFL).
- 分析了与AHI相关的风险特征和地理位置.
主要成果:
- 在大多数听觉,前庭,认知或视觉功能测试或血液生物标志物水平中,没有发现AHI和对照组之间的显著差异.
- 患有AHI的参与者报告疲劳,抑郁,创伤后压力,失衡和神经行为症状显著增加.
- 28%的AHI患者出现功能神经障碍,根据事件特征或位置没有显著变化.
结论:
- 虽然大多数客观测量和生物标志物没有显著差异,但患有AHI的个体经历了失衡,疲劳,抑郁和创伤后压力等主观症状的加剧.
- 这项研究并没有复制先前研究的所有发现,可能是由于参与者群体和评估时间的差异.
- 需要进一步的研究来了解AHI的复杂性及其对健康的影响.
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