埃德蒙顿症状评估系统是一个有效,可靠和响应的工具,用于评估不补偿性肝硬化症的症状负担
John Donlan1, Chengbo Zeng2, Teresa Indriolo3
1Harvard Medical School, Boston, Massachusetts, USA.
Hepatology communications
|March 18, 2024
概括
修订后的埃德蒙顿症状评估系统 (ESAS-r) 有效地测量了不补偿性肝硬化 (DC) 患者的症状负担. 这种经过验证的工具可以预测生活质量的变化,帮助临床护理和研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床评估 临床评估
- 心理测量 心理测量 心理测量
背景情况:
- 脱补偿性肝硬化 (DC) 患者面临显著的症状负担.
- 缺乏用于DC的症状评估的有效工具,这阻碍了有效的干预.
- 经过修订的埃德蒙顿症状评估系统 (ESAS-r) 在DC患者中被评估其心理特征.
研究的目的:
- 为了研究ESAS-r的心理特征,在一个带有不补偿性肝硬化患者的纵向队列中.
- 评估ESAS-r在这个群体中的可靠性,有效性和响应能力.
主要方法:
- 成年门诊DC患者被前性地招募.
- 在基线和12周后,ESAS-r被使用.
- 被检查的心理测量属性包括可靠性,有效性 (结构性,已知组,收性,预测性),地板/天花板效应以及使用验证规模 (SF-LDQOL,HADS,PHQ-9) 的响应性.
主要成果:
- ESAS-r表现出强大的可靠性 (克朗巴赫α 0.86) 和结构有效性 (CFI 0.95).
- 已知组的有效性被确立 (p=0.006),并收的有效性很强 (r=-0.67与SF-LDQOL).
- ESAS-r得分预测了SF-LDQOL的变化 (β=-0.36,p<0.001) 并显示出强烈的响应性.
结论:
- ESAS-r是一个可靠,有效和响应的工具,用于评估不补偿性肝硬化患者的症状负担.
- 它可以有效地预测健康相关生活质量的变化.
- 建议在肝硬化治疗和临床试验中实施ESAS-r.
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