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Updated: Jun 30, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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TLK-ASF1基因组伴侣通路在IL-1β介导的AML进展中发挥着关键作用

Hsin-Yun Lin1,2,3,4,5, Mona Mohammadhosseini1,2,3,4,5, John McClatchy1,2,3,4,5

  • 1Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

Blood
|March 18, 2024
PubMed
概括

针对TLK1-ASF1通路,对于急性髓性白血病 (AML) 炎症信号至关重要,提供了一个有前途的治疗策略. 抑制这种途径可以减少AML亚型的白血病细胞生长,而不会损害正常的血液形成.

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