阿加罗-寡糖化合物通过调节肠道微生物群和增强小鼠肠道屏障功能来缓解脱氧尼瓦诺诱导的肠道炎症
Qingfeng Wang1,2, Yanwei Wang1,2,3, Yue Wang1,2
1State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. shimengh@cau.edu.cn.
Food & function
|March 18, 2024
概括
阿加罗-寡糖化物 (AgaroS) 通过改善肠道屏障功能和改变肠道微生物群来保护免受脱氧尼瓦伦醇 (DON) 引起的肠道损伤. 这项研究表明,AgaroS是对肠道健康有前途的抗菌素策略.
科学领域:
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 来自阿加罗斯的阿加罗-寡糖糖 (AgaroS) 具有抗氧化和抗炎性质.
- 脱氧尼瓦伦醇 (DON) 是一种致使肠道功能障碍的真菌毒素.
- 对抗DON引起的肠损伤的AgaroS的保护作用尚不清楚.
研究的目的:
- 研究AgaroS对小鼠在DON引起的肠功能障碍的保护作用.
- 探索AgaroS在减轻DON毒性的潜在机制.
主要方法:
- 小鼠被分为四组:对照组,AgaroS,DON和AgaroS + DON.
- 在28天的时间里,AgaroS是口服的.
- 从第21天到第28天,DON gavage诱导了肠道损伤.
- 测量包括体重,血细胞因子,状的高度,以及肠道屏障标记物和增殖标记物的蛋白质表达.
主要成果:
- 在接受DON治疗的小鼠中,AgaroS补充剂改善了体重,并降低了血炎性细胞因子.
- DON显著降低了阴道的高度,但AgaroS减轻了这种影响.
- 阿加罗斯增加了在大肠和大肠中的克劳丁,奥克卢丁,Ki67和mucin2的表达.
- AgaroS调节了肠道微生物群的组成,增加了短链脂肪酸的产生.
结论:
- 在小鼠中,AgaroS补充剂减轻了DON引起的肠炎症和损伤.
- AgaroS增强了肠道屏障功能,并调节了肠道微生物群.
- AgaroS代表了一种潜在的抗菌毒素方法来维持肠道健康.
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