相关实验视频

Updated: Jul 15, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.3K

设计,合成和生物评估的MNK-PROTACs

Xue Sun1, Qingyun Wu2, Hong Bu2

  • 1Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, China.

Molecular diversity
|March 18, 2024
PubMed
概括

新的蛋白质分解向嵌合体 (PROTACs) 通过降解基激活蛋白激酶 (MAPK) 相互作用激酶 (MNKs) 提供了一种新的癌症治疗策略. 化合物II-5显示出显著的抗增殖作用和MNK1降解,突显了MNK-PROTACs的潜力.

关键词:
这是一种抗瘤药物.在MNK1/2基因酶中,MNK1/2基因酶是这就是PROTAC.在 eIF4E 中,您可以使用 eIF4E.

更多相关视频

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.2K
Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes07:22

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Published on: January 12, 2024

3.4K

相关概念视频

Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...