皮甲状腺暴露与成年人骨矿物质密度和骨质疏松症的相关性
Zhubin Shen1, Fengyi Zhang2, Xiaoqing Guan2
1Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China. shenzb21@mails.jlu.edu.cn.
Journal of bone and mineral metabolism
|March 18, 2024
概括
甲状腺暴露与较低的骨矿物质密度 (BMD) 和骨质疏松症风险增加有关. 像跨-DCCA和4-F-3PBA这样的特定代谢物在各种骨部位显示出与BMD的负面关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 骨健康 骨健康 骨健康
背景情况:
- 甲状腺杀虫剂被广泛使用,引发了对潜在健康影响的担忧.
- 骨矿物质密度 (BMD) 是骨健康的关键指标,低BMD与骨折风险增加有关.
研究的目的:
- 调查成年人暴露于铁类药物和骨矿物质密度 (BMD) 之间的相关性.
- 为了检查特定的铁甲状腺代谢产物和骨质疏松症风险之间的关系.
主要方法:
- 从NHANES (2007-2014) 对1389名50岁以上的参与者进行了横截面研究.
- 测量了三种甲酸代谢物:3-基酸 (3-PBA),转-3-(2,2-二维尼尔) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 转-3-基酸 (4-F-3PBA),转-3-(2,2-二维尼尔) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- 使用多变量回归和贝叶斯核机器回归 (BKMR) 来分析与 BMD 和低 BMD (骨质疏松症) 的关联.
主要成果:
- 较高水平的跨-DCCA和4-F-3PBA与整个大腿骨,大腿骨部和整个脊椎的BMD负面相关.
- 超DCCA暴露与低BMD (骨质疏松症) 的风险增加有显著的相关性.
- 经过BKMR分析,混合甲基暴露与低骨质量之间存在积极趋势.
结论:
- 甲状腺暴露与BMD水平有负相关性.
- 铁类药物对骨损伤和骨质疏松症风险的影响因特定的代谢物,度和骨部位而异.
- 这些发现突显了与环境甲状腺暴露相关的潜在骨风险.
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