怀孕期间明显的甲状腺功能低下症和后代的语言发育:有联系吗?
S Menotti1,2, C Mura3,4, S Raia3,4
1Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy. sara.menotti@guest.policlinicogemelli.it.
Journal of endocrinological investigation
|March 18, 2024
概括
孕妇在怀孕期间的甲状腺功能低下与不良分娩结果有关,包括更高的子宫内生长限制 (IUGR) 风险和较低的APGAR分数. 后代的神经发育,特别是语言技能,可能会受到负面影响,与母亲的甲状腺刺激激素 (TSH) 水平相关.
科学领域:
- 内分泌学 在内分泌学.
- 神经发育儿科 神经发育儿科
- 产科 产科 产科 产科 产科
背景情况:
- 怀孕期间的过度甲状腺功能低下会导致产科并发症的风险,例如早产和胎儿死亡.
- 孕产妇甲状腺功能低下症对后代智商 (IQ) 和语言发育的影响受到争论.
- 了解母亲治疗的甲状腺功能低下症对儿童神经发育的长期影响至关重要.
研究的目的:
- 调查怀孕期间接受治疗的母体甲状腺功能低下症与后代神经发育之间的关联.
- 专门研究对学习和语言发展的影响.
- 探索相关的孕产妇产科并发症.
主要方法:
- 31名甲状腺功能低下妇女 (TSH>10mU/L) 与21名甲状腺功能良好女性对照 (TSH0.5-2.5mU/L) 的比较.
- 使用格里菲斯-II尺度评估后代的神经发育.
- 对怀孕结果和产科并发症的分析.
主要成果:
- 甲状腺功能低下的母亲分娩较早 (38.2 vs. 40周),出生体重较低 (2855.6 vs. 3285克),子宫内生长限制 (IUGR) 的比率更高,剖腹产的次数更多.
- 甲状腺功能低下的母亲的孩子有较低的1分钟APGAR分数 (8.85比9.52).
- 神经认知评估显示,甲状腺功能低下的母亲的孩子的得分较低,特别是在学习和语言 (子表C) 中,母体TSH较高和较低的得分之间存在相关性.
结论:
- 低甲状腺母亲的胎儿面临IUGR的风险增加和APGAR分数的降低.
- 神经认知发育,特别是语言,似乎比一般发育系数受影响更大.
- 观察到的神经发育变化与母亲甲状腺功能低下症的严重程度和持续时间相关.
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