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Updated: Jun 30, 2025

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
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A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

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大酶B降解细胞外基质,促进炎症和胆道新血管化

Gideon Obasanmi1, Manjosh Uppal1, Jing Z Cui1

  • 1Department of Ophthalmology and Visual Sciences, UBC, Vancouver, BC, Canada.

Angiogenesis
|March 18, 2024
PubMed
概括

向Granzyme B (GzmB),一种在与年龄相关的黄斑变性 (AMD) 中升高的蛋白酶,可能为新血管AMD (nAMD) 提供一种新的治疗方法. 在临床前模型中,抑制GzmB降低了胆道新血管化.

关键词:
与年龄相关的黄斑变性.血管新生的产生.冠状腺新血管化疗法细胞外矩阵是细胞外矩阵.大酶B 种子炎症 炎症是一种炎症.巨细胞是最重要的细胞.

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