3型血清杆菌肺炎在结合疫苗时代的人口结构,2001-2018年
Eleonora Cella1, Catherine G Sutcliffe2, Lindsay R Grant2
1Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida.
Microbial genomics
|March 18, 2024
概括
由3型血清型引起的侵入性肺炎球菌病 (IPD) 在纳瓦霍民族中仍然存在. 自2010年以来,Clade II菌株在成人和儿童中增加,这表明基因组变化推动了疾病趋势.
科学领域:
- 基因组流行病学基因组流行病学
- 传染病的动态传染病的动态
- 公共卫生微生物学
背景情况:
- 侵入性肺炎球菌病 (IPD) 仍然是一个重大的健康负担,特别是在土著人群中.
- 尽管有13肺炎球菌合疫苗 (PCV13),但3型血清仍在美国西南部土著社区引起IPD.
- 2010年后,纳瓦霍民族成年人中3型血清型IPD的发病率增加,在儿童中持续存在.
研究的目的:
- 分析纳瓦霍民族3型血清分离体的基因组流行病学.
- 确定类成员身份并评估血清型3人口结构随时间变化 (2001-2018) 的变化.
- 为了研究特定的血清型3类和疾病/携带趋势之间的关联.
主要方法:
- 从携带和IPD病例中分离的血清型3的全基因组测序.
- 纳瓦霍民族的129名成人和63名儿童的隔离样本分析 (2001-2018).
- 确定分类成员 (分类II,分类Iα,非CC180) 和评估人口结构的时间变化.
主要成果:
- 确定了三种主要的血清型3亚群:Clade II (46.9%),Clade Iα (30.7%) 和一个非CC180类 (22.4%).
- 在2001-2010年至2011-2018年期间,与II类相关的IPD在成年人中显著增加 (23.1%至71.8%).
- 在同一时期,与II类相关的携带在儿童中显著增加 (23.3%至52.6%),在成年人中显示非显著增加 (0%至50.0%).
结论:
- 自2010年以来,血清型3的Clade II在纳瓦霍民族的患病率有所增加.
- 这种Clade II的增加与成年人IPD病例和儿童携带病例的增加有关.
- 血清型3内的基因组进化可能导致运载和疾病模式的观察变化.
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