深度大脑刺激对语言的影响:感知和声学数据
Yunjung Kim1, Austin Thompson2, Ignatius S B Nip3
1School of Communication Science and Disorders, Florida State University, Tallahassee.
Journal of speech, language, and hearing research : JSLHR
|March 18, 2024
概括
深度大脑刺激 (DBS) 在帕金森病 (PD) 中对语言的影响很小. 虽然一些声学测量略有变化,但大多数人没有经历显著的语音变化,突出显示了语音间的变化.
科学领域:
- 神经学 神经学
- 语音科学 语言科学
- 生物医学工程 生物医学工程
背景情况:
- 帕金森病 (PD) 经常导致语言障碍.
- 深度大脑刺激 (DBS) 是PD运动症状的常见治疗方法.
- DBS对PD患者语音产生的影响仍然是研究领域.
研究的目的:
- 为了研究帕金森病患者进行深度大脑刺激时的言语变化.
- 使用客观和主观措施,比较DBS-On和DBS-Off条件之间的语音特征.
主要方法:
- 来自44名听众的听觉感知评分 (语音质量,口音,歌词,可理解性,倾听力度).
- 对9名患有DBS的PD患者的语音录音进行声学分析 (比较DBS-On与DBS-Off).
- 关键的声学指标包括发音比例,母音分散,发音率和频率/强度范围.
主要成果:
- 在DBS-On和DBS-Off条件之间的感知语音评分没有显著差异.
- 六个声学测量中的四个显示了统计学上显著的变化.
- 发音速度和母音分散增加,而发音比例和强度范围在DBS-On下降;然而,这些变化在大多数参与者中并不一致.
结论:
- 对于患有帕金森病的人来说,深部大脑刺激通常会导致言语产生无至微小的变化.
- 语音特征和对DBS的反应的显著互音者变化是一个关键因素.
- 需要进一步的研究来了解DBS对PD语言的微妙影响.
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