相关实验视频
Updated: Jun 30, 2025
11:19
Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
11.5K
抗抑郁药对牙科植入物失败的影响:系统性审查和元分析
The International journal of oral & maxillofacial implants
|March 18, 2024
概括
抗抑郁药的使用,特别是选择性血清素再吸收抑制剂 (SSRI),与明显更高的牙植入物失败风险有关. 这一系统性审查强调了在使用这些药物时接受牙科植入程序的患者的潜在并发症.
科学领域:
- 在口腔外科手术.
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
背景情况:
- 牙植入成功对于恢复功能和美观至关重要.
- 抗抑郁药物被广泛处方,选择性血清素再吸收抑制剂 (SSRI) 是一个常见的类别.
- 系统性药物和手术结果之间的潜在相互作用需要彻底调查.
研究的目的:
- 系统地审查和元分析有史以来使用抗抑郁药的患者牙植入物失败的风险.
- 量化抗抑郁药使用与牙科植入物失败率之间的关联.
- 探索基于抗抑郁药类型的潜在风险差异.
主要方法:
- 在PubMed/MEDLINE,Web of Science和Cochrane控制试验中央注册表中进行了全面的电子文献搜索,截至2023年6月.
- 包括的研究比较了使用抗抑郁药和不使用抗抑郁药的患者的牙科植入物失败率.
- 进行了元分析,以计算患者和植入物水平的风险比率,评估异质性.
主要成果:
- 在分析中包括了11项研究.
- 在患者 (2.44) 和植入物 (2.44) 两种水平上都观察到牙植入物失败的风险比率显著增加.
- 亚组分析表明,单独使用SSRI或与其他抗抑郁药物结合使用,与非使用者相比,增加了植入物失败的风险.
结论:
- 包括SSRI在内的抗抑郁药的使用与牙植入物失败的风险增加有关.
- 这些发现表明,在考虑植入牙的患者中,需要仔细考虑抗抑郁药的使用.
- 需要进一步的研究来确认特定的SSRI影响,并阐明潜在的机制.
相关概念视频
01:23Antidepressant Drugs: MAOIs and Other Agents
228
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
228
01:25Antidepressant Drugs: Overview
477
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
477
01:28Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
384
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
384