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固体器官移植中的组织居民巨细胞:有害还是保护性?

Sistiana Aiello¹, Ariela Benigni¹, Giuseppe Remuzzi¹

¹Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Journal of immunology (Baltimore, Md. : 1950)

|March 18, 2024

概括

移植器官含有捐赠组织居民巨细胞 (TRMs),影响器官的接受或拒绝. 了解TRM的起源和功能是改善移植结果的关键.

科学领域:

免疫学免疫学免疫学
移植生物学移植生物学
巨细胞生物学巨细胞生物学

背景情况:

移植器官将捐赠者的免疫细胞,主要是组织寄存型巨细胞 (TRMs) 引入受体.
TRMs在确定移植接受与拒绝方面的确切作用尚未完全理解.
TRM的来源多样化,包括胚胎和骨髓前体,影响其移植后的行为.

结论:

巨细胞群,特别是供体TRM和受体单细胞衍生的MF,在器官移植结果中发挥着关键但独特的作用.
对这些巨细胞动态的进一步研究可以指导促进移植接受的策略.
澄清巨细胞在移植中的起源和功能对于推进该领域至关重要.

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