肺功能受损的COVID-19康复者的1年随访:一个前性队列研究
Nitzan Karny Epstein1, Dana Yelin2, Dorit Shitenberg3
1Infectious Diseases Unit, Meir Medical Center, Kfar-Saba, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Infectious diseases now
|March 18, 2024
概括
幸存者COVID-19经常减少一氧化碳扩散能力 (DLCO). 虽然有一些肺功能在一年内得到改善,但许多人仍然表现出DLCO受损,特别是那些肥胖的人.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 长时间的COVID研究
背景情况:
- 减少一氧化碳的扩散能力 (DLCO) 是COVID-19后常见的肺部异常.
- 了解DLCO损伤的长期轨迹对于管理COVID-19康复者至关重要.
研究的目的:
- 评估COVID-19康复后一年肺功能受损的个体DLCO的变化.
- 确定与DLCO改善或不改善相关的因素.
主要方法:
- 在COVID-19后3个月和1年,对51名DLCO受损的个人进行前性随访.
- 对DLCO百分比变化和正常化率的分析.
- DLCO变化与症状和肥胖的相关性.
主要成果:
- 平均DLCO在一年内从68.0%增加到72.6% (p=0.002).
- 33%的患者表现出临床显著的DLCO升高,但只有29%的患者正常化.
- 缺乏DLCO改善在肥胖患者中更为常见.
结论:
- 很大一部分COVID-19康复者在一年后仍然有DLCO受损.
- 虽然发生了一些功能恢复,但完全正常化是罕见的.
- 肥胖可能是阻碍COVID-19后患者DLCO恢复的一个因素.
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