作为MAPK信号传导中的C-RAF激酶的新型相互作用因子和候选抑制剂,SIRT4

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Updated: Jun 30, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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Mehrnaz Mehrabipour1, Saeideh Nakhaei-Rad2, Radovan Dvorsky1

  • 1Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.

Life science alliance
|March 18, 2024
PubMed
概括

科学家发现SIRT4与C-RAF相互作用,抑制RAF/MEK/ERK通路. 这表明SIRT4通过调节C-RAF-MAPK信号传递来作为细胞结合性瘤抑制剂.

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