肺功能从童年到成年期中期的不同轨迹
Xian Zhang1,2, Andrew R Gray3, Robert J Hancox4
1Department of Preventive & Social Medicine, University of Otago, Dunedin, New Zealand.
Thorax
|March 18, 2024
概括
从童年到成年期中期的肺功能轨迹是早期建立的. 与吸烟和肥胖相关的不良模式显著增加了以后生命中气流阻塞的风险.
科学领域:
- 肺部医学 肺部医学
- 发展生物学 发展生物学
- 流行病学 流行病学
背景情况:
- 从童年到成年期中期的肺功能轨迹对于预测肺病风险至关重要.
- 了解这些生命过程模式是必不可少的,但目前有限.
研究的目的:
- 为了全面记录从童年到成年期中期的肺功能轨迹.
- 根据肺功能发展和衰退模式,确定不同的子组.
主要方法:
- 在基于人口的队列中,在多个年龄段 (9-45岁) 测量肺功能 (FEV1,FVC,FEV1/FVC) 的潜形状分析.
- 回归分析以检查已识别的轨迹,早期生活因素和成人气流阻塞之间的关联.
主要成果:
- 在1秒内确定了10种不同的强迫呼气体积 (FEV1) 轨迹,其中大多数是并行的.
- 关键的例外包括与儿童气道过敏反应相关的持续低轨迹 (3%),与吸烟和更高的BMI相关的加速下降轨迹 (8%).
- 三种FEV1轨迹有助于最低的肺功能值 (19%的队列) 占45岁时空气流阻塞的55%.
结论:
- 肺功能轨迹在青春期之前在很大程度上确定,有明显的例外,比如持续低或加速下降模式.
- 儿童呼吸道过敏反应,成人吸烟和肥胖与不良的肺功能轨迹有关.
- 这些不利的轨迹显著提高了在成年期中期发展气流阻塞的风险.
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