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什么"N"对基于MRI的动物神经成像来说是足够的?

Joanes Grandjean^1,2, Evelyn M R Lake^3,4, Marco Pagani^5,6

¹Donders Institute for Brain, Cognition, and Behaviour, Nijmegen 6500HB, The Netherlands joanes.grandjean@radboudumc.nl francesca.mandino@yale.edu.

|March 18, 2024

概括

最近的人类大脑研究引发了关于动物神经成像样本大小的辩论. 这篇意见稿探讨了在基于磁共振成像 (MRI) 的动物研究中使用大与小样本大小的对立观点.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像

背景情况:

人类大脑范围的关联研究 (BWAS) 提出了关于样本大小的伦理和科学问题.
动物神经成像领域现在正在考虑类似的样本大小辩论.

研究的目的:

介绍动物神经成像中对样本大小极端的两个对比的观点.
激发关于大样本大小对于道德和有效科学进步的必要性的讨论.

主要方法:

这是一篇观点文章,而不是经验研究.
关于基于MRI的动物神经成像样本大小的两个相反观点的讨论.

主要成果:

提出了动物神经成像中大小和小样本大小的论点.
强调科学界正在进行的辩论.

结论:

动物神经成像的最佳样本大小仍然是一个关键和争论的话题.
需要进一步讨论,以平衡动物研究中的伦理考虑与科学严谨性.

关键词:

动物神经成像动物神经成像功能磁力共振成像 (fMRI) 是一种动物动物动物样本的大小样本大小

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