杏仁体中的神经元组合允许社会信息激励以后的决策
Henry W Kietzman1,2,3,4,5, Gracy Trinoskey-Rice2,3,5, Esther H Seo2,3,5
1Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510.
概括
社会经验甚至在没有直接互动的情况下也会影响选择. 特定的大脑路径,特别是从中部前额叶皮层到杏仁体,对于这种社会驱动的决策至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 决策方式 决策方式
背景情况:
- 社会互动显著影响决策过程,即使没有直接的社会线索.
- 了解社会影响的选择背后的神经机制对于理解复杂的行为至关重要.
研究的目的:
- 在雌性小鼠中研究负责社会驱动的食物偏好的神经回路.
- 阐明前临床介质前额叶皮层 (PL) 和底侧杏仁体 (BLA) 在过去社会经验影响的选择中介的特定作用.
主要方法:
- 训练雌性小鼠将一种食物奖励与同物种相关联.
- 化学遗传技术被用来选择性地禁用从PL到BLA的投射.
- 在BLA神经元中树突脊柱密度的变化与任务执行的关系被分析.
主要成果:
- 小鼠对以前与同物种配对的食物产生了偏好,即使同物种不存在.
- 无效的PL-BLA预测取消了这种社会驱动的偏好,但保留了社会歧视.
- 在社会编码过程中激活的BLA神经元对于社会动机的奖励选择至关重要,而PL神经元在选择行为中发挥了更广泛的作用.
结论:
- PL-BLA途径对于将社会经验转化为有动机的选择至关重要.
- BLA处理专门的社会信息,而PL可以提供通用的奖励信号,促进受社会影响的决策.
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